Thyroid Disorders in Type 2 Diabetic Patients: A Study on Their Effect on Glycemic Control
Main Article Content
Abstract
Background: Thyroid disorders are common endocrine conditions that frequently coexist with Type 2 Diabetes Mellitus (T2DM). Thyroid dysfunction, whether hypo- or hyperthyroidism, can significantly affect glycemic control, complicating diabetes management. Objective: To assess the prevalence of thyroid disorders among patients with T2DM and evaluate their impact on glycemic control. Methods: A cross-sectional study was conducted among 452 Type 2 diabetic patients attending a tertiary care hospital over 12 months from January 2019 to December 2020. Thyroid function tests, HbA1c levels, and fasting plasma glucose (FPG) were measured. Patients were categorized based on their thyroid status: euthyroid, hypothyroid, or hyperthyroid. Results: Thyroid dysfunction was observed in 24.8% of T2DM patients, with hypothyroidism being more prevalent (18.4%) than hyperthyroidism (6.4%). Patients with thyroid dysfunction, particularly hypothyroidism, exhibited significantly higher HbA1c levels compared to euthyroid patients (p<0.05). Glycemic control was poorer among those with abnormal thyroid profiles. Conclusion: Thyroid disorders are highly prevalent among patients with T2DM and are associated with poorer glycemic control. Routine screening for thyroid dysfunction in diabetic patients may be essential for optimizing glycemic management and preventing complications.
Article Details

This work is licensed under a Creative Commons Attribution 4.0 International License.
How to Cite
References
Młynarska, E., Czarnik, W., Dzieża, N., Jędraszak, W., Majchrowicz, G., Prusinowski, F., ... & Franczyk, B. (2025). Type 2 Diabetes Mellitus: New Pathogenetic Mechanisms, Treatment and the Most Important Complications. International Journal of Molecular Sciences, 26(3), 1094.
Ogurtsova, K., Guariguata, L., Barengo, N. C., Ruiz, P. L. D., Sacre, J. W., Karuranga, S., ... & Magliano, D. J. (2022). IDF diabetes Atlas: Global estimates of undiagnosed diabetes in adults for 2021. Diabetes research and clinical practice, 183, 109118.
Rong, F., Dai, H., Wu, Y., Li, J., Liu, G., Chen, H., & Zhang, X. (2021). Association between thyroid dysfunction and type 2 diabetes: a meta-analysis of prospective observational studies. BMC medicine, 19, 1-13.
Biondi, B., Kahaly, G. J., & Robertson, R. P. (2019). Thyroid dysfunction and diabetes mellitus: two closely associated disorders. Endocrine reviews, 40(3), 789-824.
Pramanik, S., Ghosh, S., Mukhopadhyay, P., Bhattacharjee, R., Mukherjee, B., Mondal, S. A., ... & Chowdhury, S. (2018). Thyroid status in patients with type 2 diabetes attending a tertiary care hospital in Eastern India. Indian journal of endocrinology and metabolism, 22(1), 112-115.
Khassawneh, A. H., Al-Mistarehi, A. H., Zein Alaabdin, A. M., Khasawneh, L., AlQuran, T. M., Kheirallah, K. A., ... & Obeidat, N. (2020). Prevalence and predictors of thyroid dysfunction among type 2 diabetic patients: A case–control study. International Journal of General Medicine, 803-816.
American Diabetes Association. (2017). Standards of medical care in diabetes—2017 abridged for primary care providers. Clinical diabetes: a publication of the American Diabetes Association, 35(1), 5.
Brenta, G. (2011). Why can insulin resistance be a natural consequence of thyroid dysfunction?. Journal of Thyroid Research, 2011(1), 152850.
Iacobellis, G., Cristina Ribaudo, M., Zappaterreno, A., Valeria Iannucci, C., & Leonetti, F. (2005). Relationship of thyroid function with body mass index, leptin, insulin sensitivity and adiponectin in euthyroid obese women. Clinical endocrinology, 62(4), 487-491.
Díez, J. J., & Iglesias, P. (2012). An analysis of the relative risk for hypothyroidism in patients with Type 2 diabetes. Diabetic Medicine, 29(12), 1510-1514.
Diez, J. J., Sánchez, P., & Iglesias, P. (2011). Prevalence of thyroid dysfunction in patients with type 2 diabetes. Experimental and Clinical Endocrinology & Diabetes, 119(04), 201-207.
Duntas, L. H., Orgiazzi, J., & Brabant, G. (2011). The interface between thyroid and diabetes mellitus. Clinical endocrinology, 75(1), 1-9.
Hollowell, J. G., Staehling, N. W., Flanders, W. D., Hannon, W. H., Gunter, E. W., Spencer, C. A., & Braverman, L. E. (2002). Serum TSH, T4, and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). The Journal of Clinical Endocrinology & Metabolism, 87(2), 489-499.
Kalra, S., Aggarwal, S., & Khandelwal, D. (2019). Thyroid dysfunction and type 2 diabetes mellitus: screening strategies and implications for management. Diabetes Therapy, 10(6), 2035-2044.
Kim, B. Y., Kim, C. H., Jung, C. H., Mok, J. O., Suh, K. I., & Kang, S. K. (2011). Association between subclinical hypothyroidism and severe diabetic retinopathy in Korean patients with type 2 diabetes. Endocrine journal, 58(12), 1065-1070.
Rizos, C. V., Elisaf, M. S., & Liberopoulos, E. N. (2011). Effects of thyroid dysfunction on lipid profile. The open cardiovascular medicine journal, 5, 76.
Smithson, M. J. (1998). Screening for thyroid dysfunction in a community population of diabetic patients. Diabetic medicine, 15(2), 148-150.
Udiong, C. E. J., Udoh, A. E., & Etukudoh, M. E. (2007). Evaluation of thyroid function in diabetes mellitus in Calabar, Nigeria. Indian journal of clinical biochemistry, 22, 74-78.
Vanderpump, M. P. (2011). The epidemiology of thyroid disease. British medical bulletin, 99(1).